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interactive network visualisation
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Interactive Network Visualisation
Drugs
Targets
Pathways
Search
About / FAQ
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What is PROMISCUOUS?

PROMISCUOUS is an exhaustive resource of protein-protein and drug-protein interactions with the aim of providing a uniform data set for drug repositioning and further analysis. Our database PROMISCUOUS contains three different types of entities: drugs, proteins and side-effects as well as relations between them.

Learn more about PROMISCUOUS!

How do I explore PROMISCUOUS?

By Drug:
To search for a drug (e.g. Midodrine) go to the Drug search or the fulltext search and type in the drugs name.

By Target:
Targets as for example Fatty acid synthetase can be queried through the Target search site or for example by UniProt ID through the fulltext search as well.

By Pathway:
To browse PROMISCUOUS targets by pathway affiliation go to the pathway site, choose an organism (e.g. Homo sapiens) and then the desired pathway (e.g. mTOR signaling pathway).

watch video tutorial

Watch the video tutorial


Reference

PROMISCUOUS: a database for network-based drug-repositioning. [Paper]
von Eichborn J, Murgueitio MS, Dunkel M, Koerner S, Bourne PE, Preissner R.
Nucleic Acids Res. 2011 Jan;39(Database issue):D1060-6. Epub 2010 Nov 10.

What is the network visualisation?

PROMISCUOUS delivers complex relations among drugs, their respective targets and side-effects of the drugs. For each entity detailed information is given. To enable the user to explore and handle the data in a scientific yet intuitive way, we developed a novel interface that offers a "natural" way of exploring the network. Here database entities (drugs, targets and side effects) are represented as nodes in a network with edges, which represent the relations between them.

How do I enter the network visualisation?

To explore PROMISCUOUS by directly entering the network visualisation go to the Interactive visualisation site. Here you can search for drugs by their cid or for targets by their UniProt ID e.g. 2157 or FAS_HUMAN. If desired it is also possible to search for more than one target or drug by listing them separated by a semicolon (e.g. 2157;4195). Searching for a drug and a target as 2157 and FAS_HUMAN in one step is also possible by typing in the cid and the UniProt ID.

network visualisation

News

  • 05/2011: The processing-library, on which the visualisation depends, was updated. This should resolve speed-issues on some machines.
  • 04/2011: The visualisation was updated, offering new functions and the possibility to save networks as XGMML files that can be loaded into e.g. Cytoscape. The older version is still accessible here if you want to use network-files in the old format.

Why drug-repositioning?

Go to our statistics

Useful resources